High-risk genetic changes with myeloma tied to poorer outcomes

Specific abnormalities in cancer cells known to cause more aggressive disease The presence of more than one high-risk genetic abnormality is associated with dramatically more aggressive multiple myeloma, a study reported. Its findings highlight the importance of testing myeloma patients for these genetic abnormalities, helping to better understand their disease’s potential course and guiding treatment decisions, the researchers wrote. “The results of this study have enabled us to more accurately classify the aggressiveness of an individual patient’s cancer,” Martin Kaiser, MD, the study’s lead author and a professor of molecular hematology at The Institute of Cancer Research in the U.K., said in an institute news story. “We would like all myeloma patients to be able to access the newer diagnostic tests which enable clinicians to group individual patients based on their risk profile and provide treatment that is tailored to their needs.” The study, “Co-Occurrence of Cyto...